- (mythology) A fabulous creature with parts from different animals. Can be spelt chimera or chimaera.
- A griffin is a chimaera with the body of a lion and the wings and head of an eagle.
- genetics: a chimera is an organism with genetically different cells, for example, cells from two different zygotes.
- DNA or DNA products which have been put together from different genes or different organisms.
- zoology: Chimaera, a cartilaginous marine fish in the order Chimaeriformes, with a blunt snout, long tail, and a spine before the first dorsal fin.